Welcome to the Golden Gate Polymer Forum

The GGPF is a non-profit educational and scientific organization
dedicated to the study of polymeric materials and devices.

Our participants are individuals working in both industry and academia in the San Francisco Bay Area.  We sponsor monthly polymer forums, occasional symposiums or short-courses, and an email distribution list.  All interested in the study of polymers are welcome to attend.

Events

Hemoperfusion with Polymeric Adsorbents (Robert Ward, ExThera Medical)

“Hemoperfusion with Polymeric Adsorbents in the Treatment of Drug-Resistant Bloodstream Infections”

Robert Ward
President and CEO
ExThera Medical Corporation

Abstract
ExThera Medical Corporation of Martinez, CA has developed the Seraph® Microbind® Affinity Blood Filter (Seraph). Seraph is a broad-spectrum biomimetic hemoperfusion device that removes (drug-resistant) pathogens, toxins and pro-inflammatory cytokines from whole blood. It is designed to reduce the intensity and duration of bacterial and viral infections in the prevention and treatment of sepsis, a major cause of death all over the world. Methods of polymer surface modification and characterization we previously applied in the development of blood and tissue-contacting medical devices were useful in the creation of Seraph. Synthetic methods that maximize surface concentration of macromolecular ligands while avoiding stearic hindrance were needed for the successful creation of a non-porous, antithrombogenic adsorption media that mimics the binding sites used by pathogens when they invade the human body. Seraph is currently undergoing clinical trials in Europe. Preclinical testing of a related device, Seraph 200, was performed by Battelle Columbus within the DARPA Dialysis-like Therapy (DLT) Program where it demonstrated excellent safety and efficacy in the removal of methicillin resistant Staph. aureus (MRSA).

Speaker Background

Bob Ward is president of ExThera Medical in Martinez, and founder of Berkeley-based Polymer Technology Group (PTG), now DSM Biomedical. Bob is a chemical engineer and polymer scientist with 44 years of experience in the development and manufacturing of medical devices, and polymeric biomaterials for critical applications. Novel biomaterials and components developed and manufactured under his direction have been used in dozens of devices and prosthetic implants including artificial hearts, vascular grafts, stents, pacemakers, orthopedic implants and contact lenses. ExThera, his fourth start-up venture, has developed Seraph, a dialysis-like sorbent hemoperfusion device that safely removes pathogens and toxins from blood in the treatment of drug-resistant bacteremia and viremia. European clinical trials are currently underway.

Date:

Thursday, February 11

Location:

Michael's Restaurant at Shoreline Park
2960 N. Shoreline Park
Mountain View, CA 94043

Map

Timing:

6 PM social hour
7 PM dinner
8 PM lecture

Cost:

Employed/postdoc Student/unemployed/retired
Early Registration  $30 $15
Registration $35 $20
Walk-in (not guaranteed) $40 $25

Lecture-only is free.

 

Payment:

We accept cash or checks at the door, or online payment via credit card. No-shows are responsible for full payment of registration fee.

Registration:

Please register below or contact:

David Olmeijer
email: dolmeijer@gmail.com
phone: 415-509-8948

Deadline for registration:

11:59PM, Wednesday, February 3 for early registration discount.
5PM, Wednesday, February 10 for regular registration.

Dinner Selection:

Seafood - Tilapia with Mango SalsaD
Chicken - Chicken Cacciatore
Vegetarian - Eggplant Parmagiana

You should receive confirmation of your registration; if not, please contact us again.

Price: $0.00

Date: February 11, 2016

Address:
Michael's at Shoreline
Michael's Restaurant at Shoreline Park
Mountain View, CA
94043 Map and Directions

Available Spaces: Unlimited

Designing Simple Polymers with Protein-like Activity (Prof. Greg Tew, UMass)

“Designing Simple Polymers with Protein-like Activity: Advanced materials and new therapies”

Prof. Gregory N. Tew
Polymer Science and Engineering Department
University of Massachusetts, Amherst

Abstract
Our primary research aim is to create new materials using a combination of principles, many of which are inspired by biology. In addition, the design of simple molecules that mimic the complex structures and functions of biology is at the heart of our work. In this presentation, we will illustrate some of these principles including novel networks with high resilience and new delivery agents inspired by protein transduction domains (PTDs). Coupling high efficiency click chemistry with telechelic polymer design generates new phase separated networks that are highly elastic and have bicontinuous morphologies over a very wide compositional range. PTD designs rely on synthetic approaches that easily allow doubling the density of guanidine functional groups, which increases the transduction efficiency of the sequences. Cellular uptake studies on three different cell lines (HEK 293T, CHO, and Jurkat T cells) confirm that these synthetic analogs are highly efficient novel protein transduction domain mimics (PTDMs), that are more effective than TAT49-57 and nonaarginine (R9) and also highlights the usefulness of polymer chemistry at the chemistry- biology interface.

Speaker Background

Gregory N. Tew, Professor in the Polymer Science and Engineering Department at the University of Massachusetts, Amherst, has more than a decade of experience transitioning bio-inspired design concepts to practice.
He received a B.S. in Chemistry from North Carolina State University in 1995 performing undergraduate research with Prof. D. A. Shultz and interning at Burroughs-Wellcome Pharmaceutical. In 2000, he earned his Ph.D. from the University of Illinois-Urbana under Prof. Samuel Stupp in Materials Science after which he joined the Faculty at the Polymer Science and Engineering Department at the University of Massachusetts, Amherst. Before starting there, he spent one year in William DeGrado's laboratory at the University of Pennsylvania Medical School.
His current research interests include bioinspired and biomimetic macromolecules, molecular self organization, nano-medicine, and materials-immunology. Greg received every young investigator award offered by the Federal Government including the Presidential Early Career Award for Scientists and Engineers (PECASE) which is the highest honor recognized by Federal Funding Agencies for young faculty and presented by the White House. He was elected as a member of the Defense Science Study Group, founding member of the ACS Polymer Chemistry Division Fellows program, and served as board chair of the ACS Division of Polymer Chemistry. More recently he has elected fellow of the ACS and AIMBE. He has published over 150 peer-reviewed papers and serves as chair of the SAB for PCCL, Polymer Competence Center Leoben, Austria. Greg remains interested in technology transfer activities and mentorship. He was a scientific and original co-founder of PolyMedix; a clinical-stage biotechnology company which has raised over $150M as well as founding mentor of Future Faculty Workshop: Diverse Leaders of Tomorrow.

Date:

Friday, March 11

Location:

Michael's Restaurant at Shoreline Park
2960 N. Shoreline Park
Mountain View, CA 94043

Map

Timing:

6 PM social hour
7 PM dinner
8 PM lecture

Cost:

Employed/postdoc Student/unemployed/retired
Early Registration  $30 $15
Registration $35 $20
Walk-in (not guaranteed) $40 $25

Lecture-only is free.

 

Payment:

We accept cash or checks at the door, or online payment via credit card. No-shows are responsible for full payment of registration fee.

Registration:

Please register below or contact:

Lothar Kleiner
email: lothar_kleiner@hotmail.com
phone: 650-492-9400

Deadline for registration:

11:59PM, Thursday, March 3 for early registration discount.
5PM, Thursday, March 10 for regular registration.

Dinner Selection:

Seafood - Monterey Snapper with Marinara
Chicken - Chicken Jalapeno with Red Pepper Sauce
Vegetarian - Spinach and Mushroom Crepes

You should receive confirmation of your registration; if not, please contact us again.

Price: $35.00

Date: March 11, 2016

Address:
Michael's at Shoreline
Michael's Restaurant at Shoreline Park
Mountain View, CA
94043 Map and Directions

Available Spaces: Unlimited

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