"Engineered Porous Polymers Promote Healing and Regeneration:
A Rethinking of Biocompatibility and Tissue Engineering"
Prof. Buddy D. Ratner
Dept. of Bioengineering and Chemical Engineering
University of Washington
Tissue engineering has been with us for over 30 years and yet, I spite of some clinical successes, it has had little impact on the day-to-day practice of clinical medicine. This has been attributed to translational issues in scale-up and production, i.e., high costs; incompletely developed technologies and regulatory concerns. The concept of in situ tissue engineering is attractive in that it utilizes the patient’s own cells and also the patient’s own body as the bioreactor. Sphere templated porous polymers (STPP), where all interconnected pores are approximately 40 microns in diameter, have been found upon implantation to be rapidly infused with macrophages which then, in about 1 month, leads to vascularized, reconstructed tissue. Larger and smaller pore size materials do not demonstrate this phenomenon. Implantation of 40 micron pore STPP in bone sites yielded bone. Implantation in sclera yielded sclera tissue. Implantation in skin showed reconstruction of both the dermis and epidermis. Implantation in heart led to reconstruction of the heart stroma. Recent investigation of this in situ tissue engineering reconstruction demonstrated that major changes are occurring in RNA signals from cells in 40 micron pores, compared to cells in 80 micron pores. Also, unique cells morphologies are seen in different pore sizes. Finally, there is evidence that the macrophages may be differentiating to an endothelial-like lineage contributing to the vigorous blood vessel ingrowth. The results of these experiments open new insights into biocompatibility and tissue engineering. (coauthors on this work include James Bryers, Neal Beeman and Le Zhen)
Dr. Buddy D. Ratner is the Director of University of Washington Engineered Biomaterials (UWEB21) Engineering Research Center, co-director of the Center for Dialysis Innovation (CDI) and the Darland Endowed Chair in Technology Commercialization. He is Professor of Bioengineering and Chemical Engineering, University of Washington. Ratner received his Ph.D. (1972) in polymer chemistry from the Polytechnic Institute of Brooklyn. Ratner is a fellow of the American Institute of Medical and Biological Engineering (AIMBE), AVS, AAAS, ACS, POLY and the International College of Fellows Biomaterials Science and Engineering. In 2002 Ratner was elected a member of the National Academy of Engineering, USA. He has been involved in the launch of seven companies and won numerous awards including the AVS Welch Award (2002), Society for Biomaterials Founders Award (2004), the BMES Pritzker Distinguished Lecturer Award (2008), the Acta Biomaterialia Gold Medal (2009), the Galletti Award (2011) the George Winter Award of the European Society for Biomaterials (2012)and the University of Washington School of Medicine Lifetime Innovator and Inventor Award (2014). He served as President of Society For Biomaterials in 1998 and AIMBE in 2002. His research interests include biomaterials, tissue engineering, regenerative medicine, polymers, biocompatibility, surface analysis and plasma thin film deposition.
Monday, February 11
Michael’s at Shoreline
2960 N Shoreline Blvd
Mountain View, CA