Welcome to the Golden Gate Polymer Forum

The GGPF is a non-profit educational and scientific organization
dedicated to the study of polymeric materials and devices.

Our participants are individuals working in both industry and academia in the San Francisco Bay Area.  We sponsor monthly polymer forums, occasional symposiums or short-courses, and an email distribution list.  All interested in the study of polymers are welcome to attend.


Rheological Characterization of Respiratory Secretions in Severe SARS-CoV-2 (COVID-19) Infections by Prof. Andrew J. Spakowitz, Stanford University


Rheological Characterization of Respiratory Secretions in Severe SARS-CoV-2 (COVID-19) Infections

Prof. Andrew J. Spakowitz

Departments of Chemical Engineering and Materials Science & Engineering,
Stanford University

Thursday, October 21, Webinar at 6:30 PM Pacific time


Thick, viscous respiratory secretions are common in severe cases of COVID-19 disease and greatly contribute to breathing difficulty. Understanding the polymeric composition and the rheological properties of these secretions can inform the development of treatments to improve the respiratory function of these patients. After measuring the composition of respiratory secretions collected from intubated COVID-19 patients and controls, we found that DNA content and hyaluronan content were greatly elevated in COVID-19 sputum. Across all patients, COVID-19 sputum exhibited a wide distribution in rheological properties, which were measured using dynamic light scattering microrheology. Respiratory secretions from COVID-19 patients had a statistically significant increase in storage moduli compared to healthy controls. We explored the possibility of reducing sputum viscosity by treating the aspirates enzymatically with hyaluronidase or DNase, which degrade hyaluronan and DNA, respectively. Interestingly, there was a strong positive correlation between the shear modulus of COVID-19 sputum and the effect of these enzymes. These results suggest that DNA and hyaluronan may be viable therapeutic targets in COVID-19 infection and could be targeted with FDA-approved enzymes already clinically used for other indications.

Speaker Background:

Prof. Spakowitz received his Ph.D. from CalTech, and is a Professor in both departments of Chemical Engineering and Materials Science & Engineering at Stanford University. The Spakowitz research group is engaged in projects that address fundamental chemical and physical phenomena underlying a range of biological processes and soft-material applications. Current research in his research group focuses on four main research themes: chromosomal organization and dynamics, protein self-assembly, polymer membranes, and charge transport in conducting polymers. These broad research areas offer complementary perspectives on chemical and physical processes, and they leverage this complementarity throughout their research. This approach draws from a diverse range of theoretical and computational methods, including analytical theory of semiflexible polymers, polymer field theory, continuum elastic mechanics, Brownian dynamics simulation, equilibrium and dynamic Monte Carlo simulations, and analytical theory and numerical simulations of reaction-diffusion phenomena. A common thread in the work is the need to capture phenomena over many length and time scales, and flexibility in research methodologies provides them with the critical tools to address these complex multidisciplinary problems.


EVENT DATE: Thursday, October 21

Registration deadline: Tuesday, October 19, 1:00 PM.

Registration may close earlier than the nominal deadline if capacity is reached.

This event will be FREE OF CHARGE, but we still require you to fill out the registration form. In particular, we need to have your name and email address for you to be able to participate. Please provide affiliation also if you can, as it helps us judge audience interests.

If you can spare a small amount, GGPF requests an optional donation of $5 (or more) but this is not required to register and attend the webinar.

To register for free, use the pull-down toggle to select "All registrants ($0.00)" choice.

To donate, use the pull down toggle to select "GGPF donation ($5.00)". This will direct you to a link where you can use PayPal or any credit or debit card. For larger donations, use the "Donate to GGPF" link on the front page GGPF.org

Webinar Timing: Webinar Time 6:30 PM.

(Zoom meeting room will open earlier)

Attendees who complete the registration form will receive information by email for how to participate. It is requested that people join the meeting invitation well before 6:00 to avoid delays.

Registrants will receive the information needed to join the webinar within a day of the event in an email from “events@ggpf.org” To be certain of seeing the note, please add events@ggpf.org to your safe mail senders list, and/or look in your spam, updates, or other mailbox locations in addition to your primary In Box.

Please register on the web page.

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For questions or other assistance, contact:

Steve Sinton

Attendees will be added to the GGPF email announcements list unless they request otherwise.


Anywhere you want, or anywhere you are busy socially distancing, sheltering in place, working, or waiting it all out. Good luck!

Price: $5.00

Date: October 21, 2021

Available Spaces: 886

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