Folding Sequence-Defined Peptoid Polymers into Protein Mimetic Nanostructures
Dr. Ronald Zuckermann
Biological Nanostructures Facility, The Molecular Foundry
Lawrence Berkeley National Laboratory
Thursday, September 30, Webinar at 6:30 PM Pacific time
A longstanding challenge in molecular biomimicry is to build synthetic nanostructures with the same architectural sophistication as proteins. One of the most promising ways to do this is to synthesize sequence-defined, non-natural polymer chains that, like in nature, spontaneously fold and assemble into precise three-dimensional structures. This was originally a synthesis problem, but the automated solid-phase submonomer synthesis method now allows one to efficiently synthesize high-purity, sequence-defined peptoid polymers up to 50 monomers in length. The method uses readily available primary amine synthons, allowing hundreds of chemically diverse side chains to be cheaply introduced.
This remarkable synthetic capability raised the next problem: which chemical sequences in a chain encode for precise folding into a 3D structure? This is essentially the protein folding problem extended to the non-natural world. Using results from our synthetic capabilities in concert with computational modeling and high-resolution characterization techniques, we will discuss the design, synthesis, assembly, and engineering of a variety of protein-mimetic nanostructures. We show by direct cryo-TEM imaging, AFM, NMR, and x-ray scattering, that all known crystalline peptoid assemblies share a universal secondary structure motif, the cis-Sigma strand, based on a backbone fold containing all cis-amide bonds. The unexpected universality of peptoid backbone folding offers a unique opportunity to rationally design and engineer these materials to create robust nanomaterials capable of protein-like functions, such as specific molecular recognition and catalysis.
Cryo-TEM image of the molecular packing in the core of a peptoid nanosheet.
Ronald Zuckermann is a Sr. Research Advisor at the Molecular Foundry at the Lawrence Berkeley National Laboratory, where he studies the mimicry of biological architectures using bio-inspired polymers. He received his BS in Chemistry in 1984 from Harvey Mudd College where he did undergraduate research in synthetic organic chemistry. He then went on to UC Berkeley to study Bioorganic Chemistry with Prof. Peter Schultz. His thesis work was on the synthesis of semi-synthetic nucleases capable of the sequence-specific cleavage of RNA. After receiving the first Schultz group PhD in 1989, he became one of the founding chemists at Protos Corp., a combinatorial drug discovery start-up in Emeryville, CA. There he helped develop several key drug discovery technologies such as robotic combinatorial library synthesizers, affinity selection methods, and a novel class of heteropolymers called "Peptoids". Chiron Corp. acquired Protos in 1991 where this work continued and was applied to small molecule drug discovery, new biomaterials, and nucleic acid delivery. Dr. Zuckermann was promoted to Research Fellow in 2003. In early 2006, he left Chiron to direct the Biological Nanostructures Facility of the Molecular Foundry at Lawrence Berkeley National Laboratory to do research at the interface of chemistry, biology and nanoscience. There he pioneered the field of peptoid nanostructure, folding sequence-defined peptoid polymer chains into protein-like nanoarchitectures. He has published over 180 papers and is co-inventor on 38 patents.
EVENT DATE: Thursday, September 30
Registration deadline: Tuesday, September 28, 1:00 PM.
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Presented by Prof. Timothy Long, Arizona State University; Prof. David A. Dillard, Virginia Tech; Prof. Mike Bortner, Virginia Tech; Dr. Giles Dillingham, BTG Labs
3-Day Live Virtual Short Course,
October 26, 27 and 29, 2021 (Tuesday, Wednesday, and Friday)
Sponsored by the Golden Gate Polymer Forum.
This 3-day virtual course will address the fundamentals and applications of adhesion science to solve practical adhesive design and bonding challenges. The course will be taught by a well-coordinated team of highly experienced instructors, and will focus on four fundamental perspectives: adhesive structure-property relationships (Long), surface functionalization and characterization (Dillingham), polymer rheology and processing (Bortner), and design and mechanics of adhesive bonds (Dillard). The course will allow participants to gain a broad perspective of the rapidly evolving field of adhesion science and engineering for emerging technologies from electronics to biomedical sciences.
All topics will be presented with an application/use-inspired approach to foster learning, including by those with limited directly relevant technical education or experience. Attendees can expect to learn about surfaces and interfaces, polymer structure-property relationships relevant to adhesives, and the stresses and failure of adhesive joints. Building on these fundamental insights, participants will gain many practical insights into surface preparation, time-dependent adhesive characterization, test method selection, surface and failure analysis, joint design, and adhesive durability. (See detailed topics list in course outline below.)
This course offers an exceptional opportunity with a unique combination of four very experienced researchers/teachers from renowned polymer and adhesion science research programs across the nation, a virtual format to allow broad participation, an affordable price, and a focus on practical applications. Q&A sessions will be incorporated throughout each day.
Who should attend:
Any scientist, engineer or technician who works with bonding, joining, or adhesion issues, including those using polymeric adhesives or sealants, and their use in a research, development, product design, manufacturing, quality control, or reliability context.
Managers in polymer and manufacturing industries will greatly benefit from this broad-based introduction to adhesion issues and opportunities in the field.
The course is structured for those with some scientific or engineering background and those with industrial experience in technology who would like to learn the basics and fundamentals of adhesion science and applications to practical adhesive bonding and engineering challenges.
Dr. Timothy Long holds a joint faculty position in the School of Molecular Sciences and the School for Engineering, Matter, Transport and Energy at Arizona State University. Prof. Long leads the Biodesign Center for Sustainable Macromolecular Materials and Manufacturing within the Biodesign Institute at ASU. His interdisciplinary research group tackles diverse research areas related to the structure-property-processing relationships of polymers with emphasis on sustainable chemistry and engineering, discovery of novel synthetic methods, advanced physical characterization tools, and designing materials with proper reactivity and rheology for additive manufacturing processes. His research has led to over 50 patents and 350 peer-reviewed publications in diverse areas of macromolecular science and engineering. His distinctions include Virginia 2019 Outstanding Faculty Award, American Chemical Society (ACS) PMSE Cooperative Research Award, ACS Division of Polymer ChemistryPOLY Mark Scholar Award, and ACS Fellow (2009).
Dr. David A. Dillard is the Adhesive and Sealant Science Professor in the Biomedical Engineering Science and Mechanics Department at Virginia Tech. He has worked extensively in the field of adhesive bonding, having experience in structural adhesives for aerospace, automotive, and infrastructure applications; adhesives and coatings for microelectronic applications; pressure sensitive adhesives; elastomeric adhesives and sealants, and polymeric membranes, sealants and adhesion issues in alternative energy systems. He has coauthored over 200 publications in refereed journals and regularly teaches courses in adhesion science and viscoelasticity. His research activities focus on developing test methods and predictive models for understanding and estimating the performance and durability of adhesives and bonded joints, using the principles of fracture mechanics and viscoelasticity. He is a Robert L. Patrick Fellow and former President of the Adhesion Society
Dr. Michael J. Bortner is an Associate Professor of Chemical Engineering who specializes in structure-process-property relationships of polymer composite and nanocomposite materials for applications including smart materials and electronics, structural composites, next generation extrusion based additive manufacturing materials, and packaging materials. He implements advanced processing and characterization techniques coupled with numerical modeling to fundamentally understand the interrelationships between intrinsic chemistry-controlled properties, processing technique, and resulting morphology/structure-property relationships. He has over 50 peer reviewed journal manuscripts and conference papers and proceedings, and was recently elected Treasurer of the American Chemical Society Cellulose and Renewable Materials (ACS CELL) Division. He has served as the Chair of the Structural Division of the Adhesion Society and is currently co-chair of the Adhesion Society Annual Meeting.
Dr. Giles Dillingham has worked in the areas of materials, surfaces, interfaces, and adhesive bonding since receiving his Ph.D. in Materials Science in 1987. BTG Labs, established by Dr. Dillingham in the late 1990’s, performs basic and applied research in surface science, surface treatments, and adhesion, and also develops and manufactures instrumentation for the control of surface engineering processes. Recent work by BTG Labs is helping pave the way to certifiable adhesively bonded primary aircraft structures. Dr. Dillingham has over 40 publications and patents in the areas of surface treatments, surface energetics, and adhesion. He is proud to have been elected a Robert A. Patrick Fellow of The Adhesion Society.
Do not reply to this email. See below for contact information.
Class size will be larger than typical in-person events, but GGPF reserves the option to close registration if the size gets too large in our opinion.
Registration deadline dates are tiered, with early, regular, and late registration fees.
Overall Course Schedule
Tuesday, Oct. 26 – Introduction to Adhesion Science
7:30 AM – 6:00 PM Pacific time
Wednesday, Oct. 27 – Adhesion Structure and Characterization
8:00 AM – 6:00 PM Pacific time
Friday, Oct. 29 – Adhesive Processing and Durability
8:00 AM – 5:30 PM Pacific time
Detailed Topics Schedule
(possible slight changes in timing)
Day 1: October 26 - Introduction to Adhesion Science
· Polymeric Adhesive Design: Introduction to Terminology (Long1)
· Water-borne and Photoreactive Systems: Sustainability (Long4)
· Rheological Impact of Additives and Chemorheology of Network Forming Polymers (Bortner5)
· Process Control for Adhesion (Dillingham4)
EVENT DATES: October 26, 27 and 29 (Tuesday, Wednesday, and Friday)
Class materials will be presented using Zoom. Registrants will receive webinar information shortly before the class begins.
Pricing and Deadlines:
$400 early registration, ending Friday, July 16, 5 PM Pacific time.
$500 regular registration, till Monday, October 4, 5 PM Pacific time.
$600 late registration, if still available, until Tuesday, October 19, 5 PM Pacific time.
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No registrations allowed after 5 PM Oct 19 or if class size reaches a practical limit.
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The Golden Gate Polymer Forum (GGPF) is a successful 40-year non-profit educational organization dedicated to the study of polymeric materials and devices. We sponsor well attended monthly polymer forums, and annual symposiums or short-courses. The GGPF attracts scientists, engineers, and sales professionals (from start-ups to Fortune 100 companies), as well as academics, all of whom are interested in the study of and advancements in polymer science, materials, or engineering. GGPF events, in addition to providing a forum for cutting edge research and industry practices, allow for collaborative networking. The majority of our attendees are from the Bay Area, yet we attract people from out of state as well as international guests, thanks to our reputation in the industry as a premier and easily affordable educational forum.