Sensing with Artificial Pores - Prof. Lydia Sohn


The Golden Gate Polymer Forum announces the September Dinner Lecture: 

"Sensing with Artificial Pores – From Single Molecules to Single Cells" 
Prof. Lydia Sohn 
  Dept. of Mechanical Engineering, U. C. Berkeley
       Thursday, Sept. 21

       Michael's Restaurant at Shoreline Park, Mountain View

Biological processes often depend on sparse interactions involving as little as a single molecule. One example is “sensory processing” or the transduction of stimuli such as odor, light, and sound into a cellular response. Such processing centers on transmembrane pore proteins or ion channels that are so finely tuned that they can open or close in response to only one molecule. This level of sensitivity is truly remarkable and serves as inspiration for developing artificial nanopores for molecular

In this talk, I will describe a fundamentally different artificial pore my group has developed within an integrated microfluidic chip. Our pore spans the length scales of “micro” to “nano” and is easily and reliably fabricated in either quartz substrates or polydimethylsiloxane (PDMS). I will show our pore’s ability to detect the binding of unlabeled antibody-antigen pairs as well as the ability to sense single molecules of unlabeled lambda-phage DNA.  Finally, I will discuss one current application of our pore upon which we are focusing:  screening specific cell-surface markers of cells.



DATE:      Thursday, Sept. 21
Location:   Michael's Restaurant at Shoreline Park,   Mountain View 
(see directions below).

Timing:        6 PM  social hour
                     7 PM  dinner
                     8 PM  lecture

Cost:              $30 with advance registration
                  Half price for students, retired, and unemployed.
                  Free if you attend just the lecture at 8PM.
                           (but please let us know for headcount)
                  $35 after registration deadline
, if possible.  

DIRECTIONS to Michael's at Shoreline Park:

Restaurant's web page directions

From 101 in Mountain View, take the Shoreline Boulevard
Exit toward the Bay. Drive past the Shoreline Amphitheater
and go straight ahead, entering into Shoreline Park.  After
a mile or so inside the park, a sign for Michael's will
direct you to turn left into the parking lot for Michael's

Address: 2960 N Shoreline Blvd.
Restaurant phone: 650-962-1014
Do NOT call restaurant for reservations.

PLEASE NOTE:  we accept cash or checks, but are unable to accept payment by credit card at this time.

Deadline for registration:    5 PM Tuesday Sept. 19

Please register on the web site

   see detailed registration instructions below

Or, contact:  
          Clayton Henderson


You should receive confirmation of your registration; if not, please contact us again.


Dinner choices (pick one when registering):        
       Broiled salmon, lemon beurre blanc
       Chicken Portobello
       Eggplant Parmigiana

Note that we must request that you be liable for your
registration fee if you register and do not attend;
cancellation is allowed up to the registration deadline.

We are sorry but this event is not yet open for registration.

You will be able to register starting