"Clinically Informed Bioinspired Polymers: Chemistry and Engineering"
Mark W. Grinstaff
Departments of Biomedical Engineering, Chemistry, and Medicine, Boston University, Boston, MA 02215
As an academic scientist and engineer working in interdisciplinary research, I ask questions all the time – from the most basic (how do we design small molecules to enable the synthesis of advanced materials?) to the most translational (how do we take a laboratory discovery to the clinic?). Through this process, I challenge my students and fellows to determine and elucidate the underlying chemistry and engineering principles. In this lecture, I will share our stories and successes in translating ideas from the laboratory to the preclinical and clinic setting. I begin with synthesis of unique dendrimers and dendritic-based hydrogels as adhesives for wound management, followed by the synthesis and use of polyglycerol carbonates for controlled drug delivery to prevent lung cancer recurrence, and, finally, ROMP to prepare large molecular weight polyanions as lubricants for cartilage surfaces and the potential treatment for osteoarthritis. In each section, I will highlight the design requirements, the synthetic routes and characterization data, and the performance outcomes in in vitro and in vivo experiments.
Mark W. Grinstaff is the Distinguished Professor of Translational Research and a Professor of Biomedical Engineering, Chemistry, Materials Science and Engineering, and Medicine at Boston University. He is also the Director of BU’s Nanotechnology Innovation Center, the Director of the NIH T32 Biomaterials Program, and the Associate Director for Engineering and Science at the BU Cancer Center. Mark's awards include the ACS Nobel Laureate Signature Award, NSF Career Award, Pew Scholar in the Biomedical Sciences, Camille Dreyfus Teacher-Scholar, Alfred P. Sloan Research Fellowship, the Edward M. Kennedy Award for Health Care Innovation, and the Clemson Award for Applied Research. He is a Fellow of the American Institute of Medical and Biological Engineering, the American Academy of Nanomedicine, and the Royal Chemical Society, and a Founding Fellow of the National Academy of Inventors. Over the course of his tenure, Grinstaff’s groundbreaking research has yielded more than 275 peer-reviewed publications, more than 200 patents and patent applications, and more than 325 oral presentations. His students and postdoctoral fellows have given more than 400 poster and 150 oral presentations at national and international conferences. He is a co-founder of five companies and his innovative ideas and his efforts have also led to one new FDA approved pharmaceutical (AbraxaneTM) and four medical device products (OcuSeal® and Adherus Surgical Sealants®) that improve clinical care for millions of people. His current research activities involve the synthesis of new macromolecules and biomaterials, self-assembly chemistry, imaging contrast agents, drug delivery, and wound repair.
Friday, September 14
Michael’s at Shoreline
2960 N Shoreline Blvd
Mountain View, CA
6 PM social hour
7 PM dinner
8 PM lecture
|Walk-in (not guaranteed)
Lecture-only is free.
We accept cash or checks at the door, or online payment via credit card. No-shows are responsible for full payment of registration fee.
Please register below or contact:
Deadline for registration:
End of advanced registration: Monday, September 10, 11:59 PM
End of regular registration: Thursday, September 13, 5:00 PM
Seafood - Broiled salmon with Lemon beurre blanc
Chicken - Breast of chicken with Portobello
Vegetarian - Eggplant parmesan
You should receive confirmation of your registration; if not, please contact us again.