Fast Stereolithography Printing of Large-Scale Biocompatible Hydrogels
Prof. Ruogang Zhao
Dept. of Biomedical Engineering,
University at Buffalo, SUNY
Wednesday, August 25, Webinar at 6:00 PM Pacific time
Large size cell-laden hydrogel models hold great promise for tissue repair and organ transplantation, but their fabrication using 3D bioprinting is limited by the slow printing speed that can affect the part quality and the biological activity of the encapsulated cells. Here we present a Fast hydrogeL stereOlithogrAphy prinTing (FLOAT) method that allows the creation of a centimeter-sized, multiscale solid hydrogel model within minutes. Through precisely controlling the photopolymerization condition, we establish low suction force-driven, high-velocity flow of the hydrogel prepolymer that supports the continuous replenishment of the prepolymer solution below the curing part and the nonstop part growth. The rapid printing of centimeter-sized hydrogel models using FLOAT was shown to significantly reduce the part deformation and cellular injury caused by the prolonged exposure to the environmental stresses in conventional 3D printing methods. Embeded vessel networks fabricated through multiscale printing allow media perfusion needed to maintain the high cellular viability and metabolic functions in the deep core of the large-sized models. The endothelialization of this vessel network allows the establishment of barrier functions. Together, these studies demonstrate a rapid 3D hydrogel printing method and represent a first step towards the fabrication of large-sized engineered tissue models.
Dr. Ruogang Zhao is an Associate Professor in the Department of Biomedical Engineering at the State University of New York at Buffalo. He received both of his B.Eng. and M.A.Sc. in engineering mechanics and his PhD in biomaterials and biomedical engineering from the University of Toronto. He was a postdoctoral fellow in biological physics at the Johns Hopkins University before moving to Buffalo. Through combining advanced biofabrication technologies and biomechanics, he has developed a unique research program to address the unmet need to model the physiology and pathology of mechanosensitive tissues. During his Ph.D. training, he received the prestigious Heart and Stroke Foundation of Canada Doctoral Research Award. He also received the 2019 Young Innovators Award of Cellular and Molecular Bioengineering from the Biomedical Engineering Society and Outstanding Abstract Award from the Society of Biomaterials in 2019.
EVENT DATE: Wednesday, August 25
Registration deadline: Monday, August 23, 1:00 PM.
Registration may close earlier than the nominal deadline if capacity is reached.
This event will be FREE OF CHARGE, but we still require you to fill out the registration form. In particular, we need to have your name and email address for you to be able to participate. Please provide affiliation also if you can, as it helps us judge audience interests.
If you can spare a small amount, GGPF requests an optional donation of $5 (or more) but this is not required to register and attend the webinar.
To register for free, use the pull-down toggle to select "All registrants ($0.00)" choice.
To donate, use the pull down toggle to select "GGPF donation ($5.00)". This will direct you to a link where you can use PayPal or any credit or debit card. For larger donations, use the "Donate to GGPF" link on the front page GGPF.org
Webinar Timing: Webinar Time 6:00 PM.
(Zoom meeting room will open earlier)
Attendees who complete the registration form will receive information by email for how to participate. It is requested that people join the meeting invitation well before 6:00 to avoid delays.
Registrants will receive the information needed to join the webinar within a day of the event in an email from “email@example.com” To be certain of seeing the note, please add firstname.lastname@example.org to your safe mail senders list, and/or look in your spam, updates, or other mailbox locations in addition to your primary In Box.
Please register on the web page.
You should receive email confirmation of your registration; if not, please contact us again.
Do not reply to email from email@example.com
For questions or other assistance, contact:
Attendees will be added to the GGPF email announcements list unless they request otherwise.
Anywhere you want, or anywhere you are busy socially distancing, sheltering in place, working, or waiting it all out. Good luck!