Fast Stereolithography Printing of Large-Scale Biocompatible Hydrogels
Prof. Ruogang Zhao
Dept. of Biomedical Engineering,
University at Buffalo, SUNY
Wednesday, August 25, Webinar at 6:00 PM Pacific time
Large size cell-laden hydrogel models hold great promise for tissue repair and organ transplantation, but their fabrication using 3D bioprinting is limited by the slow printing speed that can affect the part quality and the biological activity of the encapsulated cells. Here we present a Fast hydrogeL stereOlithogrAphy prinTing (FLOAT) method that allows the creation of a centimeter-sized, multiscale solid hydrogel model within minutes. Through precisely controlling the photopolymerization condition, we establish low suction force-driven, high-velocity flow of the hydrogel prepolymer that supports the continuous replenishment of the prepolymer solution below the curing part and the nonstop part growth. The rapid printing of centimeter-sized hydrogel models using FLOAT was shown to significantly reduce the part deformation and cellular injury caused by the prolonged exposure to the environmental stresses in conventional 3D printing methods. Embeded vessel networks fabricated through multiscale printing allow media perfusion needed to maintain the high cellular viability and metabolic functions in the deep core of the large-sized models. The endothelialization of this vessel network allows the establishment of barrier functions. Together, these studies demonstrate a rapid 3D hydrogel printing method and represent a first step towards the fabrication of large-sized engineered tissue models.
Dr. Ruogang Zhao is an Associate Professor in the Department of Biomedical Engineering at the State University of New York at Buffalo. He received both of his B.Eng. and M.A.Sc. in engineering mechanics and his PhD in biomaterials and biomedical engineering from the University of Toronto. He was a postdoctoral fellow in biological physics at the Johns Hopkins University before moving to Buffalo. Through combining advanced biofabrication technologies and biomechanics, he has developed a unique research program to address the unmet need to model the physiology and pathology of mechanosensitive tissues. During his Ph.D. training, he received the prestigious Heart and Stroke Foundation of Canada Doctoral Research Award. He also received the 2019 Young Innovators Award of Cellular and Molecular Bioengineering from the Biomedical Engineering Society and Outstanding Abstract Award from the Society of Biomaterials in 2019.
EVENT DATE: Wednesday, August 25
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