Events
Versatile and Sustainable Adhesives Derived from α-Lipoic Acid by Prof. Phillip B. Messersmith, University of California, Berkeley
Description:
Webinar
Versatile and Sustainable Adhesives Derived from α-Lipoic Acid
Prof. Phillip B. Messersmith
Department of Bioengineering, and Materials Science and Engineering Department,
University of California, Berkeley
&
Materials Sciences Division, Lawrence Berkeley National Lab
Wednesday, October 9, Webinar at 6:00 PM Pacific time
Abstract
Polymer adhesives play an important role in many medical, consumer, and industrial products. Polymers of α-lipoic acid (αLA) have the potential to fulfill the need for versatile and environmentally friendly adhesives, but their performance is plagued by spontaneous depolymerization. In this talk, I will describe a facile method for catalyst-free αLA polymerization, affording polymers that are resistant to spontaneous depolymerization. A small library of αLA monomer derivatives provided access to a surprisingly wide range of physical properties and uses.
I will emphasize examples where these polymers are used for use in fetal surgery. There is a growing interest in treating fetal anomalies by surgical interventions performed in the second or third trimester. Because the fetal membranes that enclose the womb are mechanically fragile and nonhealing, surgical interventions increase the likelihood of preterm premature rupture of the membranes (PPROM), which is associated with increased risk of fetal morbidity and mortality. Adhesive biomaterials are being explored to seal iatrogenic fetal membrane defects, as a way to provide mechanical stability to the membranes, reduce amniotic fluid loss, and extend gestation. Interestingly, our new αLA surgical glue successfully sealed murine amniotic sac ruptures, increasing fetal survival from 0% to 100%.
αLA polymers create new opportunities in the context of consumer and industrial adhesion. 20M tons of polymer adhesives are produced every year, most of which are destined for the waste stream and ultimately landfilled, incinerated, or discarded into the environment. αLA monomer composition could easily be tailored to afford high performance pressure sensitive and structural adhesives. Furthermore, αLA adhesives can be sustainably sourced and recycled in a closed-loop manner at >80% monomer recovery, suggesting that αLA adhesives could be more eco-friendly than existing commercial adhesives.
Speaker Background
Phillip Messersmith is a Professor of Bioengineering and of Materials Science and Engineering at UC Berkeley, where he is currently chair of the Department of Bioengineering. He earned his BS and PhD degrees from the University of Illinois at Urbana. After a postdoctoral fellowship at Cornell University, he was a faculty member at University of Illinois, Chicago and at Northwestern University. He has published over 220 papers, and is a fellow of the Royal Society of Chemistry, the Materials Research Society, and the American Institute for Medical and Biological Engineering. His awards and honors include a MERIT award from the National Institutes of Health, the Langmuir Lecture Award from the American Chemical Society, and the Clemson Award for Basic Research from the Society for Biomaterials. His academic research is focused on bioinspired materials, biointerfacial phenomena, and regenerative medicine. He has 47 US patents awarded and is the cofounder of three startups.
DATE: Wednesday, October 9
Registration deadline: Tuesday, October 8, 1:00 PM.
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Webinar Timing: 6:00 PM.
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