Laser Capture Microdissection - Polymers in Medical Research and Diagnostics


Monthly Dinner Meeting
Wednesday, December 6, 2000


A double header for December:
two shorter talks on polymer materials as used
in two newer companies.

Please note the short response time:
Event date - Wednesday evening, Dec.6
Registration requested by 9 AM, Tuesday, Dec.5.

"Laser Capture Microdissection - Polymers in
Medical Research and Diagnostics"
Robert Reamey, Arcturus Engineering, Inc.


"The Use of Polymers in Alien Technology"
Gordon Craig, Alien Technology Corp.



Laser Capture Microdissection - Polymers in
Medical Research and Diagnostics

Robert Reamey
Arcturus Engineering, Inc.

As our understanding of cell function at a molecular
level has grown in recent years, more and more
sophisticated questions about the molecular basis of cell
function are being asked. This trend continues to drive
the need for techniques to isolate pure cell populations
from complex biological samples. Laser Capture Micro-
dissection (LCM) is a new tool for isolating pure cell
populations for molecular analysis. At the heart of
LCM is the interaction between a polymer film and a laser.
The laser-polymer interaction results in an increase of
the adhesion between the polymer and the tissue only in the
areas of exposure to the laser, enabling selective capture
of desired regions of tissue or of specific cells. The DNA,
RNA, and protein from the captured cell populations can
then be extracted for molecular analysis. In this talk,
I will provide an overview of Laser Capture Microdissection,
describe some of it's applications, and discuss the role of
the polymer in making the technology work.

"The Use of Polymers in Alien Technology".
Gordon Craig,
Alien Technology Corp.

Alien Technology Corporation has developed a manufacturing
assembly technology called Fluidic Self Assembly (FSA)
that allows for the efficient placement of arbitrarily
large numbers of small components of one material across
a different material surface in a single operation. While
there are many potential applications of FSA, such as
antennas, sensors, and RFID tags, Alien Technology is
focusing initially on manufacturing displays. Because
FSA can work on plastic substrates, Alien Technology will
combine the FSA process with standard roll-to-roll plastic
processing to make displays that combine the high
performance of single crystal silicon transistors with the
low cost of plastic substrates. In addition, these displays
will be flexible, such that they could be used in a number
of applications for which conventional LCD's would not work.
Needless to say, polymers play significant roles throughout
the Alien Technology display manufacturing process. I will
briefly described some of the requirements of the polymeric
materials used for the substrate material, the FSA
process, the display dielectric material, and the display
material itself. I will describe in more detail a polymer
planarization system designed specifically for reflow to
fill gaps.



Cost: $30 ($15 for unemployed/retired/students)

Social Hour: 6:00 PM
Dinner: 7:00 PM
Talk: 8:00 PM

Dinner: Chinese Buffet - no advance choice required.
(there will be vegetarian items)

Location: Hewlett Packard
1501 Page Mill Road, building 3L
Palo Alto.

Attendance for the talk alone at 8 PM is free; we ask
that you contact us for headcount purposes. Please
be explicit about attending only the talk if that is
the case, so we don't count you for dinner. Please try
to arrive no later than the nominal start time of 8 PM.


From 101:

Take Oregon Expressway exit toward ocean (SW), go
several miles; at El Camino Real Oregon Expressway
becomes Page Mill Road. Keep going across El Camino;
about 3 traffic lights further, at the top of a hill,
turn left at Peter Coutts Road into the well-marked
Hewlett-Packard entrance (Peter Coutts Road actually
only goes to the right). Visitor parking lot is the
first allowed left turn after the gate; the lobby is
close by. After 6:30 there should not be any
security guard outside but you will have to wait for
escort from the lobby.

From 280:

Take the Page Mill Road exit toward the bay (NE), and
pass 3 traffic lights (the second will be Junipero
Serra). Turn into Hewlett-Packard entrance at the 4th
light and proceed as described above (turning right
when coming from this direction, of course)

Visitors will have to come to the main lobby desk and
sign in. There may or may not be passes prepared
ahead of time. Someone will check periodically for
latecomers in the lobby, but you won't be able to get
in instantaneously without escort, so allow a little
time for that process.


- Make reservations by 9 AM Tuesday, Dec. 5

- Please provide contact information (email or phone),
name, and affiliation.

- You should receive confirmation of your registration;
if not, please try again.

- Register through the web site (preferred),

or contact:
Nayan Ashar

- We must ask you to be liable for the cost of
your dinner if you register and do not attend;
cancellations may be made up to the registration


Other events of possible interest to the
GGPF audience:

Nov. 29, Palo Alto
Software demonstration by CAChE: Prediction of
physical, chemical, and biological properties
with computer aided chemistry.
Free, but registration required; contact
Heidi Klein,, 503-746-3603

Nov. 29, Berkeley
ACS dinner lecture:
"New Tricks in the Old Chemistry of Photography",
U.C. Berkeley Prof. Emeritus William L. Jolly

Dec. 7, Emeryville
Bay Area Mass Spectroscopy (BAMS) dinner mtg:
"Proteomics in a Boutique Laboratory"
Catherine Fenselau, University of Maryland

Dec. 7, Santa Clara
SPE sponsored tour of INTEL museum

Dec. 13, UC Extension, Sunnyvale
Noon-5 PM short course:
"Materials Issues in Semiconductor Packaging"
by Prof. Guna Selvaduray, SJSU

Dec. 13, Sunnyvale
IEEE/CPMT Dinner Meeting:
"IC Packaging Roadmaps" --
Dave Tovar, IPAC

Dec. 13, Sunnyvale
ASM Dinner Meeting
"Recovery of the Challenger Shuttle Data Tapes"
Rick Brackshaw
more regular chemistry & magnetic media, but a
great story.>

A little out of the area, but included here due to
repeated questions:

Dec. 9-13, Hawaii
POLY Millennial 2000
(ACS Polymer Division 2000 Biennial Meeting)

Dec. 14-19, Hawaii
Pacifichem 2000 Meeting, Honolulu, HI
(includes six or more POLY Sessions)

---- 2001 -----

Jan. 10, Sunnyvale
ASM dinner meeting
"Beyond Silicon: Microfabrication with Metals,
Plastics, and Ceramics"
Alfredo Morales, Sandia National Laboratories

Jan. 10, Cupertino
AIChE dinner meeting
Thomas Gutshall, CEO of Cepheid, will speak on
chemical engineering in the Biotech industry

Feb. 2-3, 2001 Stanford
4th Annual Paul Flory Conference
on Physical and Macromolecular Chemistry

Feb. 4-6, 2001, Stanford
Stanford Polymer Short Course
(right after the Flory Symposium)

Feb. 5-9, Santa Clara
AVS 2nd International Conference on Microelectronics
& Interfaces

Feb. 15-20, San Francisco
AAAS annual meeting


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