In Vivo Glucose Sensors Based on Electrical


April GGPF Dinner Lecture:

Thursday, April 18
Michael's at Shoreline
Mountain View

"In Vivo Glucose Sensors Based on
Electrical "Wiring" of Glucose Oxidase"

Prof. Adam Heller

Dept. of Chemical Engineering & Texas Materials Institute,
The University of Texas, Austin


The requirements of a glucose sensor, subcutaneously self- implanted and replaced twice a week by a diabetic patient,
include: absence of leaching of any its components; absence
of fouling during the intended period of use; maintenance
of a 2-30 mM glucose sensing range; a response time shorter than 2 min; pre-calibration or simple one-point calibration in the body; <5% drift of the sensitivity through the entire sensing range between in-vivo calibrations; a size small enough (< 0.4 mm diameter) to avoid pain upon implantation; insensitivity to change in the concentrations of any of the chemicals in the subcutaneous interstitial fluid other than glucose; invariance of the reading with temperature, motion, oxygen partial pressure and easy insertion and removal by the patient. The electrical connection ("wiring") of the redox centers of glucose oxidase to the tip of a fine gold or carbon wire, in combination with a precisely engineered layer-by-layer assembled micromembrane, provides a basis for meeting these criteria. The micromembrane allows simultaneous optimization of the linear range, the apparent engineering life, the drift (variation of the sensitivity with time), and the sensitivity to interferants. It also excludes interferants, and reduces the influx of serum components that damage the electrocatalyst. Reproducible micro-membranes can be formed on the tips of fine wires coated with the wired glucose oxidase by sequential chemisorption of polycation/ polyanion bilayers. Sensors of 0.05 mm2 area have been engineered with the micro-membranes to simultaneously provide a sensitivity of 3 nA/mM, a linear dynamic range of 1-30 mM; drift of less than 5% of the current per day, and sufficient operational stability to eliminate the need to recalibrate the sensor for three days. When the sensors are over-coated with thin glucose permeable film of polyethylene oxide and are heparinized, their subcutaneous or intravenous implantation provides for accurate measurement of the glycemia in rats and in a diabetic chimpanzee.



DATE: Thursday, April 18

Location: Michael's at Shoreline Park, Mountain View

Timing: 6 PM social hour
7 PM dinner
8 PM lecture

Cost: $30
half price students, retired, unemployed
free for just the lecture at 8PM
(but please let us know for headcount)

Deadline for registration: 5PM, Monday, April 15.

Please register on the web site
Otherwise, register by contacting
Hilary Lackritz

You should receive confirmation of your registration; if not, please contact us again.


Dinner choices:
broiled salmon
chicken portabello
vegetarian Napoleon (eggplant, polenta, vegetables)

Note that we must request that you be liable for your registration fee if you register and do not attend; cancellation is allowed up to the registration deadline.


From 101 in Mountain View, take the Shoreline Boulevard
Exit, turning toward the bay. Drive past the Shoreline Amphitheater and go straight ahead, entering into Shoreline Park. After a mile or so inside the park, a sign for Michael's will direct you to turn left into the parking lot for Michael's.
Address: 2960 N Shoreline Blvd.
Restaurant phone: 650-962-1014
(do not call restaurant for reservations)


Preliminary announcement:

May 30 at San Jose State University
all-day event

GGPF Spring Symposium:
"Polymers in MEMS and Sensor Applications"

Speakers include
Richard M. Crooks, Texas A&M
Tom Kenny, Stanford University
Kevin Killen, Agilent
Liwei Lin, U. C. Berkeley
Ken Shea, U.C. Irvine
And more

Further details to be announced; or, contact
Hilary Lackritz,,
for further information.


April 11, Foster City
Special Short Course, 9:00AM to 3:30PM

"Using Thermal Analysis to Characterize
Pharmaceutical Materials"

Recent innovations in thermal analysis instrumentation have significantly improved the utility and performance of thermal analysis as a tool in characterizing various pharmaceutical materials. Len Thomas of TA Instruments will present a 1-day seminar on the application of various thermal techniques in characterizing pharmaceutical materials.

Leonard C. Thomas is Vice President of Applications Development at TA Instruments, Inc.

The course fee is $100.00 per person. GGPF, BATAS and NATAS members will receive a discount of $25.00 from the course fees. Please provide e-mail from GGPF or BATAS indicating your inclusion.

For more information, or to register, contact
Kendra Savage,
fax 302-427-4186.


OTHER EVENTS of possible interest to the
GGPF audience:


March 21, Santa Clara
ACS Santa Clara Valley section
David Rakestraw, Eksigent Technologies,
"Microscale Chemical Analysis -
Can We Make a Laboratory on a Chip?"

March 22, Pleasanton
Seminars/Exhibitors/Workshops/Education Night Dinner


April 1-5, S.F.
Materials Research Society spring national meeting
Many sessions of interest.
April 5-6, S.F.
Associated MRS Workshop: Materials Issues in MEMS

April 10, Sunnyvale
IEE/CPMT dinner meeting,
"Emerging Packaging Challenges: The 2002
Semiconductor Packaging Roadmap"
Joseph Adam, Conexant

April 10, San Jose
PTI short course
"Fundamentals of MEMS Design & Fabrication"
April 11, San Jose
PTI short course
"Introduction to Optical MEMS
for BioSensing and Communications"

April 25, Lafayette
Northern California ACS dinner lecture
"From Metallocenes to Cytotoxicity in Mouse-Cell Leukemia:
An Intimate View of Academic Research & Some Bay Area
Chemical Urban Legends" Prof. R.E. Bozak, California State University Hayward


May 5-9, S.F.
Society of Plastics Engineers
Annual Technical Conference (ANTEC)

May 8 (Concord?)
ASM Golden Gate Section dinner meeting
Adam Schwartz, LLNL, "Electron Backscatter


June 21, San Jose
PTI short course
Fundamentals of Photolithography

June 23-28, Monterey
Electrochemical Society
11th International Meeting on Lithium Batteries


July 14-16, Stanford
July 14, short course
July 15-16, conference
Photonic Devices & Systems Packaging Symposium

July 17-18, San Jose
International Electronics Manufacturing
Technology Symposium

July 17-19, San Jose
SEMICON - Backend/final manufacturing focus
July 22-24, S.F.
SEMICON - Wafer fab focus


Join the GGPF announcements list through the web page
or by replying to this announcement with your name and preferred email address.

Send any suggestions for events that should be
mentioned in these announcements to

We are sorry but this event is not yet open for registration.

You will be able to register starting